Category Archives: Medical

CorpPharma: Evil Incarnate

A while ago I wrote the attached post which explains when
open markets make sense (capitalism) and when social systems make sense (socialism):

https://anonymole.com/2017/01/07/when-open-markets-make-sense/

Subsequently, I was not surprised to find supporting evidence of this theory.

The CorpPharm company Pfizer, recently exhibited the exact behavior outlined in that post: If a life saving, life benefiting drug is not profitable, or about to be released for generic production, thereby reducing or eliminating the profit potential, then said drug will be abandoned.

Embrel is a drug to treat rheumatoid arthritis. An unintended side affect is that it most likely reduces or eliminates Alzheimers in those patients who take it (64% of those showing signs benefited). It’s about to have its 20 year exclusivity (another contentious anti-society factor) expire.

So, of course Pfizer won’t be investigating this drug for alternate use as a dementia reduction drug. It wouldn’t be profitable.

Fuck the millions of elderly who are susceptible.

Pharmaceuticals are the exact industry that should NOT be placed in the hands of capitalists.
“Give us your sick, your needy, your dying — and we will make them sicker and get rich doing it.”

https://www.washingtonpost.com/business/economy/pfizer-had-clues-its-blockbuster-drug-could-prevent-alzheimers-why-didnt-it-tell-the-world/2019/06/04/9092e08a-7a61-11e9-8bb7-0fc796cf2ec0_story.html


Earth: galactic laboratory

Here’s an alternative “Zoo” hypothesis regarding a solution to the Fermi Paradox. We’ll call it the Lab Hypothesis.

If you’ll recall, the Zoo Hypothesis is the idea that intelligent, space-faring cognizants exist and they, either a single species or a collective, have intentionally isolated Earth (we’re effectively quarantined) in order to allow humanity to sink-or-swim, as it were.

The Lab Hypothesis is similar, however, the determining factor is that outside intervention is not forbidden, only restricted. And that Earth is “mined” for the myriad lifeforms and organic compounds and molecules that are produced by those lifeforms.

Think, autonomous chemistry laboratory, which haphazardly creates and/or evolves millions of chemicals which are rare in the galaxy. These fabrications are collected by aliens (which might explain the errant sightings of spacecraft), and then sold/traded/used by other populations of intelligent races in the galaxy.

Consider that life is rare (so far — very rare). And that life itself is more capable when it comes to producing strange new chemicals. Even the most advanced AI-computers in the galaxy cannot calculate the working, stable combinations of elements that make up, say, vanilla, cinnamon, coffee, banana, okra, or cannabinoids, millions of chemical and drug compounds the corp-pharma industry searches for in the jungles of the world.

Life, nature, is just too good at making stuff up that works, on some level, to affect living beings, psychotropically, physically, or materially (spider silk for example).

So, Earth is a lab, and we’re lab-rats, and the thousands of spices, fragrances, liquids, intoxicants, etc. that we enjoy — our alien neighbors do too.

But they want to keep it a secret — and not risk polluting the petri-dish.

 


Changing the mind, again

I copied this from an email From Mr. Pollan. I’ll delete it (probably) when his book comes out in May, 2018. I’m a fan of Michael’s, I’ve read most of his books. And I’ll be reading this one.

I bothered to copy this here as the topic of “changing your mind” seems to be popular, one we’ve discussed here and on other blogger’s sites. Funny how society converges on the same thing at the same time. Maybe we’re already a hive-mind.

A Note From Michael Pollan
“A trip well worth taking, eye-opening and even mind-blowing.”
—Kirkus Reviews
Dear Readers,It’s been a while since I’ve written, but I have been busy reporting and writing a new book that I’ve just completed. I’m excited to tell you about it.

HOW TO CHANGE YOUR MIND: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence will be published in May. As the title suggests, the new book represents something of a departure for me—at least from writing about food.(As one early review put it, I’ve turned from “feeding your body to feeding your head.”)But as those of you who have been following my work for a while know, what unifies all my writing is a fascination with our symbiotic relationships with other species in nature, whether for food, beauty, or intoxication. I’ve had a long-standing interest in psychoactive plants and the age-old human desire to change the texture of consciousness. You may recall I wrote about cannabis inThe Botany of Desire and about growing opium in Harper’s several years before that.

The new book grew out of the reporting I did for a 2015 article about psychedelic psychotherapy in the New Yorker, called “The Trip Treatment.” I interviewed a number of cancer patients who, in the course of a single guided session on psilocybin (the main psychoactive molecule in magic mushrooms), had such a powerful mystical experience that their fear of death either faded or vanished altogether. I became curious to learn how that might be possible—how a molecule produced by a mushroom, of all things, could produce such a radical change in the mind of a human, such that death lost its sting.

So began what became a two-year journey into the world of psychedelics—LSD, psilocybin, Ayahuasca and something called 5-MeO-DMT. The book explores the renaissance of scientific research into these compounds and their potential to relieve several kinds of mental suffering, including depression, anxiety, and addiction. I spent time with neuroscientists who are using psychedelics in conjunction with modern brain imaging technologies to probe the mysteries of consciousness and the self. Several of the scientists I met are convinced psychedelics could revolutionize mental healthcare and our understanding of the mind.

But what I didn’t expect when I embarked on this journey was for it to result in what is surely the most personal book I’ve ever written. As you know, I like to immerse myself in whatever I’m writing—whether that means buying a steer or apprenticing myself to a baker. What began as a third-person journalistic inquiry ended up a first-person quest to learn what these medicines had to teach me about not only the mind but also my mind, and specifically about the nature of spiritual experience. This book has taken me places I’ve never been—indeed, places I didn’t know existed.

As you can imagine, I’m both excited and nervous to publish How to Change Your Mind this spring. I do hope you’ll check it out. I plan to post an excerpt on my website in a couple of months, and will alert you when I do. I’ll soon be updating the website with a rich array of resources on psychedelics. For now, though, here’s the advance review of the book from Kirkus, quoted from above.

I’ll be in touch more regularly in the next few months, to bring you news of the book as well as my extensive speaking schedule this spring. Hope to see you in person at one of these events.

All best,
Michael


Rewarding logic: Spock paradox

Why would Spock prefer a logical solution to an illogical one?

The human brain is fixated on self-reward. Our endocrine system, in concert with our cerebrum, serve to lead us in how we think and react to our world. The two systems work together to produce our behavior. There are dozens if not hundreds of hormones that serve to swill into our mind coating it and bathing it to produce drug like euphoria which, more often than not, reinforces our behavior to play-it-again-Sam.

This works for hormones like oxytocin, the more you bond with a loved one the more you want to bond; dopamine, the more you feed the reward hormone the more reward you crave; serotonin, the more content you are the more content you want to be. And there are others that behave this way. And some that go the opposite way. Ghrelin, for instance, is the hunger hormone and if you feed yourself (after being hungry), your stomach lining will stop producing it.

But what of pure thinking, logical problems? I propose that solving mental problems produces similar hormonal reward releases just as the other behaviors do. And, in fact, we know this is true; dopamine gets squirted into your system every time you see that orange dot on the wordpress bell (or fadebook or twitter or instagram, etc.). Positive feedback  during social interaction is an addictive behavior and dopamine is the culprit.

I write software. When I have a tough logical problem to crack, which I end up solving,  at that moment of realization of my breakthrough — I feel great! I just dialed up my dopamine drip. Solving logical puzzles is an addictive process. OK, maybe not addictive, but there is a reward provided by the brain when a solution is discovered.

Ah ha! moments are like a drug.

So here’s the paradox: why would Spock — as a Vulcan — prefer a logical solution if, as an emotionless being, no reward would be forthcoming for said selection?

Yes, Spock is 1/2 human, but as a Vulcan, there would be no hormonal release of a dopamine equivalent. So, why bother? If you don’t “get” anything out of choosing logic vs illogic, why be adamant about its selection? Humans, on the other hand, I believe, select a logical solution precisely because it feels good to do so. An illogical solution does not provide the reward.

Human brains and hormones work together to keep us selecting species benefiting choices. A well thought out logical solution is its own reward — because that reward feels good, it physically feels good. Spock? Vulcans? They would have no reason to pursue logic as they do.

A post of similar sentiment, that is, hormones and human response:
https://anonymole.wordpress.com/2016/10/29/your-brain-on-narrative/

 


No Money in antibiotics

Corp-Pharmaceuticals are waiting until the epidemics are eminent before they even consider wasting research and production on antibiotics. This is not across the board of course, but the trend is there. Actually ‘saving’ the world is a low priority for corporations. making money once it gets really bad — well, that’s a profitable mode of operation.

Corp-Pharma = Evil.

“Antibiotic resistance is growing, and we are fast running out of treatment options. If we leave it to market forces alone, the new antibiotics we most urgently need are not going to be developed in time.”

WHO priority pathogens list for R&D of new antibiotics

Priority 1: CRITICAL

  • Acinetobacter baumannii, carbapenem-resistant
  • Pseudomonas aeruginosa, carbapenem-resistant
  • Enterobacteriaceae, carbapenem-resistant, ESBL-producing

Priority 2: HIGH

  • Enterococcus faecium, vancomycin-resistant
  • Staphylococcus aureus, methicillin-resistant, vancomycin-intermediate and resistant
  • Helicobacter pylori, clarithromycin-resistant
  • Campylobacter spp., fluoroquinolone-resistant
  • Salmonellae, fluoroquinolone-resistant
  • Neisseria gonorrhoeae, cephalosporin-resistant, fluoroquinolone-resistant

Priority 3: MEDIUM

  • Streptococcus pneumoniae, penicillin-non-susceptible
  • Haemophilus influenzae, ampicillin-resistant
  • Shigella spp., fluoroquinolone-resistant

 

http://www.who.int/mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/

~~~

How to cure this? (ha!)

Put a society funded (government) bounty on creating effective drugs that combat drug resistant bacteria — with a guaranteed production and delivery of N numbers of doses over X number of years, all at an agreed upon ‘society benefiting’ fixed price.

Penalize drug companies that do not participate by adding additional months of FDA approval time to any drugs on the docket.

“Hey, Drug Companies! Society needs this. You’re in the business. DO IT! Or find another means to fill your shareholder’s bank accounts.”

 


WellCare SickCare

National Healthcare Idea

The current health care crisis (ACA) is in the process of being “solved” (yeah, right). I have scant knowledge of the proposed plan to fix the problem. However, talking this morning we discussed a possible alternative system which might be palatable to a fairly large percentage of participants (people, insurance, drug, government).

Split health care into two parts:

WellCare and SickCare

WellCare will be government sponsored and available without question to ALL US citizens.

SickCare will be insurance controlled and available only to those under premium/deductible payment systems.

WellCare will provide checkups, immunizations, mammograms, health screening, cancer screening, nutrition counselling, influenza shots, treatment and medication for temporary ailments. Essentially all care which keeps you healthy and/or get you back to health within a month’s time. Productivity of a society is the key here. Keeping society healthy should be the governement’s only health related goal. Beyond that is the responsibility of the individual.

SickCare takes over where WellCare leaves off – and is NOT free. Severe and/or lasting injury, long term ailments, chronic diseases should all be covered under SickCare. Society as a whole should not be held responsible for an individual’s genetic, accidental or situational conditions. Individuals must plan for extending health beyond society’s capacity for general populace care.

Where to place the dividing line between the two care systems is the critical question. If it keeps you healthy or returns you to health within one month then it is WellCare. Otherwise it is SickCare.

This is no doubt simplistic. But the core concept of two systems is sound.

Society has a responsibility – to a point – of taking care of its own. This is good economic sense. Care beyond this point however, is bad economic sense. And if a society cannot be economically viable then it will die.

Torte reform must also be part of the overall solution — got to get those lawyers out of the mix — suing doctors for profit.

Also reference:
https://anonymole.wordpress.com/2017/01/07/when-open-markets-make-sense/
https://anonymole.wordpress.com/2016/10/20/misery-profit/

 


Misery != Profit

Industries which profit from misery should not be profit seeking.

Here’s an ugly thought, and although it would never be stated as true, is true none-the-less:

• If every person on the planet became diabetic, Novo Nordisk, Sanofi, and Mannkind (among others) share holders and board members would be thrilled (they make insulin).

• If every person on earth contracted cancer, Genentech (the leading cancer drug company) and its shareholders and board members would be equally energized (despite having cancer and diabetes).

• If you STOPPED getting sick, were healthy all your days until you died of old age these pharmaceutical companies would all collapse and die AstraZeneca, GlaxoSmithKline, Merck, Pfizer, Roche, Johnson & Johnson and many others (representing nearly $500Billion in annual revenue – they MAKE that much money off of our misery every year).

There are other industries, like the entire health care system, HMOs and insurance industry. The healthcare system only makes money when you are sick or dying. The insurance industry only makes money when you THINK you are going to be sick or dying.

Lawyers who specialize in malpractice litigation are another foul industry — they only make money when you’re ill or dying AND you claim your doctor or hospital made you sicker or killed you.

For them your misery = their livelihood.

This is EVIL.

How do you fix it? It’s obvious I’m afraid. Many progressive countries have made the switch over to cure this egregious misanthropy: socialized medicine.

What entity does NOT want you to get sick, or be unhealthy causing you to be unproductive and becoming a costly burden on society? Society of course! And what is the central representation of society in every country on the planet? Government.

In a socialized healthcare system government loses money when you’re sick and can’t work, when you can’t be productive in society. So, government and the offices they create will try and make sure you are cured as quickly and effectively as possible. They’ll advance medicine and care systems to try and keep you healthy and reduce costs not increase them.

Society wants its citizens to be healthy and productive. Corporations want citizens to be sickly and profitable. Novo Nordisk does NOT want your diabetes cured — they want you to be forced to buy insulin for the rest of your life. Novo Nordisk loves the booming trend of obesity – get fat and get sick is their mantra.

That is EVIL!

Industries that make money off of our misery should be severely regulated and taxed or better yet – nationalized.